Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma‐bearing mice
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منابع مشابه
Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.
AIM To investigate the antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide (GLPP). METHODS Antitumor effect of GLPP was observed in tumor-bearing mice in vivo. At the same time, the effects of GLPP on proliferation of tumor cells and human umbilical cord vascular endothelial cell (HUVEC) were detected by MTT assay in vitro. Subsequently, spleen lymphocytes prol...
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Our previous studies demonstrated that Ganoderma lucidum polysaccharides (Gl-PS) exhibit potent immunomodulating effects. Immunomodulation plays an important role in hematopoiesis. To investigate the possible mechanism by which Gl-PS promote myelopoiesis during myelosuppression induced by cyclophosphamide, mice were injected intraperitoneally (i.p.) once daily with 2.5 mg/kg of Gl-PS for 10 day...
متن کاملAntitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum.
In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg(-1) body mass showed 80.8 and 77.6% reduction in tumour volume ...
متن کاملAntitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum
The antitumor and immunomodulatory activity of broken-spore of Ganodermalucidum polysaccharides (Gl-BSP) were investigated in vivo and in vitro. It was showed that Gl-BSP (50, 100, and 200 mg kg(-1)) exhibited antitumor effect against Sarcoma 180 (S180) in BALB/c mice. The Gl-BSP was not cytotoxicity in S180 cells and PG cells (human lung carcinoma cell) in vitro. However, serum from Gl-BSP-tre...
متن کاملAntitumor activity of the procyanidins from Pinus koraiensis bark on mice bearing U14 cervical cancer.
Pinus koraiensis Bark Procyanidins Extract (PKBPE) has been used in traditional Chinese medicine for thousands of years. In this study, we determined PKBPE effect on tumor weight, SOD (superoxidate dismutase) activity, the content of MDA (malondialdehyde) through colorimetric analysis antigenic, and expression of Ki-67, p53 and Bcl-2 on mice bearing U14 cervical cancer. Treatment with PKBPE (15...
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ژورنال
عنوان ژورنال: The Kaohsiung Journal of Medical Sciences
سال: 2019
ISSN: 1607-551X,2410-8650
DOI: 10.1002/kjm2.12020